2025 NFL Odds Week 4: Lines, Spreads for all 16 Games

NFL Week 4 kicks off Thursday night, as the Cardinals Bills host the Seahawks.

Here are the lines for every Week 4 matchup at DraftKings Sportsbook as of Sept. 21.

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(All times ET)

2025 NFL Week 4 Odds

THURSDAY, SEPT. 25

SEAHAWKS @ CARDINALS

Spread: Cardinals -1.5
Moneyline: Cardinals -122, Seahawks +102
Total O/U: 43.5

SUNDAY, SEPT. 28

VIKINGS @ STEELERS

Spread: Vikings -1.5
Moneyline: Vikings -125, Steelers +105
Total O/U: 41.5

COMMANDERS @ FALCONS

Spread: Commanders -3
Moneyline: Commanders -155, Falcons +130
Total O/U: 45.5

SAINTS @ BILLS

Spread: Bills -15.5
Moneyline: Bills -1600, Saints +900
Total O/U: 48.5

BROWNS @ LIONS

Spread: Lions -8.5
Moneyline: Lions -380, Browns +300
Total O/U: 45.5

PANTHERS @ PATRIOTS

Spread: Patriots -4.5
Moneyline: Patriots -205, Panthers +170
Total O/U: 45.5

CHARGERS @ GIANTS

Spread: Chargers -6
Moneyline: Chargers -278, Giants +225
Total O/U: 44.5

EAGLES @ BUCCANEERS

Spread: Eagles -2.5
Moneyline: Eagles -155, Bucs +130
Total O/U: 45.5